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Antiviral Activity and Mode of Action of Propolis Extracts and Selected Compounds

Aqueous and ethanol extracts of propolis were analysed phytochemically and examined for their antiviral activity in vitro. Different polyphenols, flavonoids and phenylcarboxylic acids were identified as major constituents. The antiviral effect of propolis extracts and selected constituents, e.g. caffeic acid (1), p-coumaric acid (2), benzoic acid (3), galangin (4), pinocembrin (5) and chrysin (6) against herpes simplex virus type 1 (HSV-1) was analysed in cell culture. The 50% inhibitory concentration (IC50) of aqueous and ethanol propolis extracts for HSV-1 plaque formation was determined at 0.0004% and 0.000035%, respectively. Both propolis extracts exhibited high levels of antiviral activity against HSV-1 in viral suspension tests, plaque formation was significantly reduced by >98%. In order to determine the mode of antiviral action of propolis, the extracts were added at different times during the viral infection cycle. Both propolis extracts exhibited high anti-HSV-1 activity when the viruses were pretreated with these drugs prior to infection. Among the analysed compounds, only galangin and chrysin displayed some antiviral activity. However, the extracts containing many different components exhibited significantly higher antiherpetic effects as well as higher selectivity indices than single isolated constituents. Propolis extracts might be suitable for topical application against herpes infection.

Schnitzler, P., Neuner, A., Nolkemper, S., Zundel, C., Nowack, H., Sensch, K. H. and Reichling, J. (2010), Antiviral Activity and Mode of Action of Propolis Extracts and Selected Compounds. Phytother. Res., 24: S20–S28. doi:10.1002/ptr.2868

Our Discounts are here…!

Hello dear NatureTrusters,

our discount offers are here for you!

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The Mechanism of Action of Russian Propolis Ethanol Extracts Against Two Antibiotic Resistant Biofilm Forming Bacteria. Bryan J1, Redden P1, Traba C1.

Hello dear NatureTrusters,

today we have another scientific study about the effects of propolis! Take a look…

” Abstract
The interaction between antibiotic resistant Staphylococcus aureus and antibiotic sensitive Escherichia coli biofilm forming bacteria and Russian propolis ethanol extracts was evaluated. In this study, bacterial cell death occurred when the cell membranes of Continue reading “The Mechanism of Action of Russian Propolis Ethanol Extracts Against Two Antibiotic Resistant Biofilm Forming Bacteria. Bryan J1, Redden P1, Traba C1.”

Science backs up propolis potential effects!

Hello dear NatureTrusters!

Today we have for you some more scientific information!

A writing in Clinical Reviews in Allergy and Immunology states the following for propoli’s potential effects:

“Propolis, a waxy substance produced by the honeybee, has been adopted as a form of folk medicine since ancient times. It has a wide spectrum of alleged applications including potential anti-infection and anticancer effects. Many of the therapeutic effects Continue reading “Science backs up propolis potential effects!”

When Hippocrates (460-377 BC) talked about propolis…!

Hello dear NatureTrusters!

Today we are going to tell you about the properties of propolis!

Hippocrates (460-377 BC), who is widely considered as the “Father of Modern Medicine”, wrote about the useful properties of propolis and often treated his patients with it, because he discovered that propolis could reduce pain and swelling and he could also treat ulcers and sores.

Research findings state that it is:
1. Anti-microbial – kills microbes
2. Anti-viral – kills viruses
3. Anti-bacterial – kills bacteria
4. Anti-inflammatory – reduces swelling
5. Anaesthetic – reduces sensations of pain
6. Regenerative – heals wounds
……blah blah blah….You don’t need to know all of these! Just Trust Nature and you will see…

Well, class is over for now! Enjoy and TrustNature…!

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What is contained in Propolis?

 

Hello dear NatureTrusters!

Today we are going to tell you what is contained in propolis! So here is the list of substances:

1. Different types of resins and balm – 50%
2. Different types of beeswax – 25-35%
3. Essential oils – 10% Continue reading “What is contained in Propolis?”

Meaning of the word ” Propolis “

 

Hello dear NatureTrusters!

Today we will explain to you what does ” propolis ” mean!

” Propolis ” breaks down to two words, ” Pro-polis “.
” Pro ” in greek means ” before ” and ” polis ” means ” city “, so bringing together the two words, what do we have…?
…let’s check it out together! Continue reading “Meaning of the word ” Propolis “”